TABLE 1.
Pharmacodynamic parameters and pharmacokinetic/pharmacodynamic indicesa
| Antimicrobial agent | P. aeruginosa strain | MIC (mg/liter) | Rmax (Δlog10 CFU/ml) | Time (h) between initial dose and Rmax | AAC0-24 (Δlog10 CFU/ml·h) | T>MIC (%) | Cmax/MIC |
|---|---|---|---|---|---|---|---|
| Meropenem | PAO1 | 0.5 | −1.09 | 1 | −22.46 | 66.67 | 112.2 |
| 12-09-15 | 2 | −1.23 | 3 | −19.58 | 41.67 | 28.05 | |
| Ceftazidime | PAO1 | 2 | −1.28 | 17.5 | 9.29 | 100 | 86.9 |
| 12-09-15 | 16 | 45.75 | 10.86 |
a
Rmax, maximal bactericidal effect; AAC, area above the curve; T>MIC, cumulative percentage of time that the drug concentration exceeds the MIC; Cmax/MIC, peak level divided by the MIC; Δlog10 CFU/ml is the difference between the log10 CFU/ml at a given time and the log10 CFU/ml of the initial inoculum.