TABLE 2.
Effect of PMPA and CMX157 on HBV replication in 2.2.15 cells and HepAD38 cells in vitro
| Compound | Mean ± SD (no. of replicates)
|
Selectivity index (CC50/EC50)
|
||||
|---|---|---|---|---|---|---|
| EC50 (μM)
|
CC50 (μM)a
|
|||||
| 2.2.15 cells | HepAD38 cells | 2.2.15 cells | HepG2 cells | 2.2.15 cells | HepG2 cells | |
| PMPA | 7.2 ± 0.8 (3) | 2.25 ± 1.24 (3) | >300 (3) | >100 (3) | >41.7 | >133 |
| CMX157 | 1.6 ± 0.2 (3) | 0.49 ± 0.24 (4) | >300 (3) | 18.8 ± 4.7 (5) | >187.5 | 38.4 |
a
The CC50s were determined in confluent 2.2.15 cells using neutral red and in rapidly dividing HepG2 cells using MTS, as described in Materials and Methods.