TABLE 2.
Noncompartmental pharmacokinetic parameters for ZDV and 3TC metabolites in subjects receiving 600 mg of ZDV and 300 mg of 3TC QD (n = 27)
| Parameter | ZDV-MP | ZDV-DP | ZDV-TP | 3TC-MP | 3TC-DP | 3TC-TP |
|---|---|---|---|---|---|---|
| Median Cmax (fmol/106 cells) | 2,997.65 | 62.47 | 43.90 | 760 | 4,424 | 4,840 |
| Median Cmin (fmol/106 cells) | 38.82 | 7.95 | 6.26 | 249 | 1,055 | 1,002 |
| Median Tmax (h) | 2 | 4 | 4 | 6 | 6 | 4 |
| Mean Tmax (h) | 2.44 | 3.48 | 4.74 | 6.30 | 6.37 | 6.67 |
| Median AUC tra | 11,883 | 627 | 502 | 10.42 | 70.01 | 65.19 |
| Mean half-life (h) ± SEM | 9.1 ± 0.85 | 17.7 ± 2.8 |
a
ZDV metabolite AUCs were calculated in femtomoles, and 3TC metabolite AUCs were calculated in picomoles.