FIG. 2.

Progeny of treated parasites produce schizonts that are unable to form functional merozoites. 3D7 strain parasites were treated with antibiotics at twice the IC₅₀ at 96 h (100 nM azithromycin, 6 μM ciprofloxacin, 25 nM clindamycin, 1 μM doxycycline, and 6 μM rifampin), and Giemsa-stained thin smears were examined every 24 h for 120 h. The times shown above panels are the numbers of hours after invasion of the first generation of parasites. Rifampin-treated parasites arrested during the trophozoite stage of the first cycle, while parasites treated with doxycycline, clindamycin, azithromycin, and ciprofloxacin arrested during the schizont stage of the second cycle.