TABLE 2.

Pharmacokinetics of antibiotics and chloroquine after standard oral dosing

Drug	Class	Antibacterial target	Dose (mg) (oral)	Avg peak plasma concn (μg/ml)	Avg peak plasma concn (μM)	Time to peak concn (h)	t1/2a	Reference(s)
Azithromycinb	Macrolide	70S ribosome (50S subunit)	1,000	0.8	1.1	2.4	74 h	11
Ciprofloxacinc	Fluoroquinolone	DNA gyrase	500	2.5	7.6	0.6	3.3 h	4, 40
Clindamycind	Lincosamide	70S ribosome (50S subunit)	600	7.4	17	1	2.6 h	28
Doxycyclinee	Tetracycline	70S ribosome (30S subunit)	200	3.2	6.9	2	7-18 h	29
Rifampinf	Rifamycin	RNA polymerase	600	6.5	8.0	1-3	3.5 h	40
Chloroquine	8-Aminoquinoline	Not applicable	300	0.076	0.24	6.6	10-24 days	40

^at_1/2, half-life.

^bGiven once daily for 3 days, alone or in combination with chloroquine for malaria.

^cGiven twice daily for 3 days in patients with bronchitis.

^dGiven twice daily for 7 days in combination with fosmidomycin for malaria.

^eGiven to patients with severe malaria.

^fGiven once daily for 15 to 18 days in patients with tuberculosis.