FIG. 1.

Alignment of the amino acid sequences and positions of dominant T-cell epitopes of ESAT-6 (A) and CFP-10 (B) of M. bovis/M. tuberculosis and M. kansasii genotypes I to V (MKA-1 to MKA-V). Amino acids are represented by the one-letter code. Promiscuous recognition of M. bovis-derived ESAT-6 and CFP-10 peptides (defined as giving rise to T-cell responses in ≥50 of the cattle tested that recognized M. bovis ESAT-6 or CFP-10) is represented by open bars above the sequences (27, 31). The proportions of animals (responder frequencies) that recognized these peptides are shown above the respective bars (27, 31). (Adapted from reference 4 with permission of the publisher.)