TABLE 3.
Animal-to-animal variation of antibody recognition of the two immunodominant antigens during experimental TB in rhesus macaques evaluated at the TNPRC and the University of South Alabama
| M. tuberculosis strain (dose [CFU]) and animal identification no. | Antibody responsea
|
|
|---|---|---|
| ESAT-6 | MPB83 | |
| Erdman (30) | ||
| 209 | ++ | − |
| 283 | ++ | + |
| 304 | + | + |
| 653 | − | − |
| 814 | + | ++ |
| Erdman (100) | ||
| 847 | + | + |
| 855 | + | + |
| 861 | − | + |
| 867 | + | − |
| 056 | − | + |
| H37Rv (210) | ||
| 590 | + | − |
| 595 | − | +++ |
| 727 | + | + |
| 729 | +++ | +++ |
a
The results for antigens eliciting the earliest antibody in each infected animal are in bold. The magnitude of the antibody response was visually scored for each antigen as very strong (+++), strong (++), weak (+), or nonreactive (−).