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. 2007 Aug 22;6(10):1727–1735. doi: 10.1128/EC.00255-07

TABLE 1.

Comparative genomic analysis of fatty acid metabolism in the Apicomplexaa

Pathway and gene product (localization) ApiDB gene IDb
Toxoplasma gondii Plasmodium falciparum Theileria annulata Cryptosporidium parvum
FASII + +
    ACP (plastid) 55.m00019 PFB0385w
    ACP PPT 20.m03796 PFD0980w
    ACP (put. mitochondrion) 59.m03510 PFL0415w
    FabB/F 83.m00002 PFF1275c
    FabD 42.m03469 PF13_0066
    FabH 44.m00012 PFB0505c
    FabI 50.m00011 PFF0730c
    FabG 37.m00770 PFI1125c
    FabZ 645.m00003 PF13_0128
FASI and PKS + +
    FASI 83.m00010 cgd3_2180
    Put. PKS 20.m03875 and additional adjacent models cgd4_2900
    Put. PKS 46.m01725
    SFP PPT 33.m01284 cgd8_4740
ELO + + +
    ELO 49.m03288 PFF0290w
    ELO 20.m00392 PFA0455c cgd8_4630
    ELO 52.m01617 PFI0980w
Malonyl-CoA + + +
    ACCase1 41.m00004 PF14_0664
    ACCase2 38.m02529 cgd8_3680
Acetyl-CoA
    PDH, E2 subunit 20.m00373 PF10_0407
    Acetyl-CoA synthetase 57.m03124 PFF1350c TA07295 cgd1_3710
Acyl-CoA + + + +
    Acyl-CoA binding protein 46.m01612, 50.m03399 PF08_0099, PF10_0015, PF10_0016, PF14_0749 TA19910 cgd1_1140
    Acyl-CoA synthetase 113.m00767, 50.m00056, 583.m00605, 583.m05329, 49.m03372, 44.m00014 PF14_0761, PF14_0751, PFC0050c, PFL2570w, MAL13P1.485, PF07_0129, PFD0085c, PFL0035c, PFB0695c, PFB0685c*, PFE1250w, PFL1880w, PFF0945c TA18970, TA15995, TA20445, TA07295 cgd4_3400, cgd3_640, cgd1_3710
a

The genomes of four apicomplexan species were mined for a broad range of fatty acid metabolism-associated genes using the BLAST algorithm and manual inspection. Note that many of these genes have been previously annotated and published (please see text for individual references). +, present; −, absent; put., putative; PPT, phosphopantetheinyl transferase; SFP, surfactin production type.

b

Gene IDs are from ApiDB at http://www.apiDB.org.

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