TABLE 1.
Comparative genomic analysis of fatty acid metabolism in the Apicomplexaa
Pathway and gene product (localization) | ApiDB gene IDb
|
|||
---|---|---|---|---|
Toxoplasma gondii | Plasmodium falciparum | Theileria annulata | Cryptosporidium parvum | |
FASII | + | + | − | − |
ACP (plastid) | 55.m00019 | PFB0385w | ||
ACP PPT | 20.m03796 | PFD0980w | ||
ACP (put. mitochondrion) | 59.m03510 | PFL0415w | ||
FabB/F | 83.m00002 | PFF1275c | ||
FabD | 42.m03469 | PF13_0066 | ||
FabH | 44.m00012 | PFB0505c | ||
FabI | 50.m00011 | PFF0730c | ||
FabG | 37.m00770 | PFI1125c | ||
FabZ | 645.m00003 | PF13_0128 | ||
FASI and PKS | + | − | − | + |
FASI | 83.m00010 | cgd3_2180 | ||
Put. PKS | 20.m03875 and additional adjacent models | cgd4_2900 | ||
Put. PKS | 46.m01725 | |||
SFP PPT | 33.m01284 | cgd8_4740 | ||
ELO | + | + | − | + |
ELO | 49.m03288 | PFF0290w | ||
ELO | 20.m00392 | PFA0455c | cgd8_4630 | |
ELO | 52.m01617 | PFI0980w | ||
Malonyl-CoA | + | + | − | + |
ACCase1 | 41.m00004 | PF14_0664 | ||
ACCase2 | 38.m02529 | cgd8_3680 | ||
Acetyl-CoA | ||||
PDH, E2 subunit | 20.m00373 | PF10_0407 | ||
Acetyl-CoA synthetase | 57.m03124 | PFF1350c | TA07295 | cgd1_3710 |
Acyl-CoA | + | + | + | + |
Acyl-CoA binding protein | 46.m01612, 50.m03399 | PF08_0099, PF10_0015, PF10_0016, PF14_0749 | TA19910 | cgd1_1140 |
Acyl-CoA synthetase | 113.m00767, 50.m00056, 583.m00605, 583.m05329, 49.m03372, 44.m00014 | PF14_0761, PF14_0751, PFC0050c, PFL2570w, MAL13P1.485, PF07_0129, PFD0085c, PFL0035c, PFB0695c, PFB0685c*, PFE1250w, PFL1880w, PFF0945c | TA18970, TA15995, TA20445, TA07295 | cgd4_3400, cgd3_640, cgd1_3710 |
The genomes of four apicomplexan species were mined for a broad range of fatty acid metabolism-associated genes using the BLAST algorithm and manual inspection. Note that many of these genes have been previously annotated and published (please see text for individual references). +, present; −, absent; put., putative; PPT, phosphopantetheinyl transferase; SFP, surfactin production type.
Gene IDs are from ApiDB at http://www.apiDB.org.