Figure 2.

There were differences in inflammatory cell infiltrates in chronically UVR-exposed nontumor skin from +/+ and Snai2-null mice. A: In both genotypes, there were markedly increased numbers of neutrophils in the chronically exposed skin, compared with the unexposed skin, in which neutrophils were rarely observed. There was no difference in the number of neutrophils between +/+ and Snai2-null mice. B: There were significantly more mast cells in the chronically exposed Snai2-null skin, compared with +/+ skin. *P = 0.05. C: Increased numbers of Cd3e-positive cells were present in the dermis after chronic UVR exposure, with significantly fewer Cd3e-positive cells in the chronically exposed Snai2-null skin, compared with +/+ skin. *P = 0.0009.