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Immunohistochemistry for Krt8 revealed widespread Krt8 expression in the unexposed skin of Snai2-null mice (A) compared with no detectable Krt8 expression in the unexposed skin of +/+ (B). There was greater Krt8 immunoreactivity in the SCC of Snai2-null mice (C) compared with SCC in +/+ mice (D). On the other hand, there was much less difference in the difference in Krt8 immunoreactivity of spindle cell tumors of +/+ mice (E) versus Snai2-null mice (F). Original magnifications, ×600.
