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. 2007 Nov;171(5):1713–1723. doi: 10.2353/ajpath.2007.070021

Figure 3.

Figure 3

Effects of TMI-2 on TNF and TNFR-1 release in cell-based conditions. A: ECV-304TNF cells were preincubated for 10 minutes with TMI-2 at concentrations ranging from 0 to 2 μmol/L and then stimulated with PMA (200 nmol/L) for 1 hour. Culture medium was collected for TNF assay. Values are mean ± SD of two separate experiments each performed in duplicate. B: Murine TACE/ADAM17+/+ and TACE/ADAM17ΔZn/ΔZn monocytic cells were preincubated with TMI-2 at concentrations ranging from 0 to 1.0 μmol/L and then stimulated with PMA (200 nmol/L) for 1 hour. Culture medium was collected for TNFR-1 assay. Values are mean ± SD of two separate experiments each performed in triplicate.