TABLE 1.
Characteristics of study participants
| Characteristic | Value for:
|
Statistical comparison | ||||
|---|---|---|---|---|---|---|
| HD | KT patient groupa
|
|||||
| All | A | B | C | |||
| No. of subjects | 16 | 38b | 16 | 27 | 23 | |
| Age (yr) at drawing of first sample | ||||||
| Median | 39.4 | 52.8 | 48.0 | 52.3 | 53.9 | NSe (HD vs all) |
| Range | 27.4-59.0 | 17.2-71.1 | 18.1-58.2 | 17.2-71.1 | 25.7-69.1 | |
| No. (%) male | 8 (50.0) | 24 (63.2) | 10 (62.5) | 17 (63.0) | 10 (43.5) | NS (HD vs all) |
| Time (wk) posttransplantationc | ||||||
| Median | 30.3 | 9.4 | 25.5 | 120.3 | P = 0.003 (A vs B); P < 0.0001 (A vs C and B vs C) | |
| Range | 2.3-462.1 | 2.3-380.7 | 4.3-449.9 | 14.0-462.1 | ||
| BKV plasma load (log cp/ml) | ||||||
| Median | Not detectable | 4.0 | 3.0 | 4.7 | 3.0 | P < 0.0001 (A vs B and B vs C); NS (A vs C) |
| Range | 3.0d-7.7 | 3.0-3.7 | 3.0-7.7 | 3.0-3.8 | ||
a
A, no/low-level replication; B, high-level replication; C, past replication.
b
For some kidney transplant recipients, samples were drawn before the onset of, during, and after high-level BKV replication. Therefore, this number is smaller than the total for groups A, B, and C.
c
Values are for all the samples in the corresponding subject group.
d
Set limit of detection; also if no plasma sample was tested.
e
NS, not significant.