FIG. 3.

Transfer of 0C3.4 cells during T. cruzi infection transiently affects the anti-SA85-1.1 antibody response but does not exacerbate tissue inflammation. Two groups of mice were inoculated with 1 × 10⁵ trypomastigotes, and 28 days later, they received either 1 × 10⁷ 0C3.4 cells or medium. (A) On days 40 and 58 of infection, sera were collected, and IgG, IgG2a, and IgG1 end-point titers to the SA85-1.1 protein were determined (data are mean titers and SE for four or more mice per group). *, P < 0.05; **, P < 0.01. (B) Also on days 40 and 58 of infection, skeletal muscles were obtained and H&E stained, inflammatory scores were determined, and results were expressed as means and SE for four muscles per group.