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. Author manuscript; available in PMC: 2007 Oct 29.
Published in final edited form as: J Biol Chem. 2006 May 27;281(30):20958–20973. doi: 10.1074/jbc.M600075200

FIGURE 11. Insulin secretion from pancreatic islets isolated from wild-type and iPLA2β-null mice that had been fed a high fat diet.

FIGURE 11

Pancreatic islets were isolated from wild-type (black bars) or iPLA2β-null (cross-hatched bars) mice that had been fed a high fat diet and incubated (30 islets/condition, 30 min, 37 °C) at a glucose concentration of 3, 8, or 20 mM in the absence or presence of 2.5 μM forskolin. Medium was then removed for measurement of insulin by radioimmunoassay. Values represent mean ± S.E. (n = 7). Single asterisk denotes p < 0.01, and double asterisk denotes p < 0.001 versus wild-type.