FIG. 3.

Evaluation of splenomegaly induced by Brucella aerosol challenge. Spleen weights of mice infected in B. abortus (A) and B. melitensis (B) aerosol kinetics studies were recorded as a measure of splenomegaly induced by the infection. The data are the averages and standard errors for all mice in a treatment group. Statistical significance was determined by ANOVA, followed by Dunnett's multiple-comparison test comparing the spleen weights of a group of five unchallenged BALB/c mice to the spleen weights of all mice receiving the same chamber inoculum dose. The dotted line represents the average spleen weight of uninfected mice (96 mg). One asterisk, P < 0.05; two asterisks, P < 0.01.