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Cytochrome bd oxidase assembly mutants of E. coli EDL933 exhibited colonization defects in competitive colonization assays. E. coli EDL933 Δ(cydD-cydC) was defective in competition with wild-type E. coli EDL933 (A) but colonized at wild-type levels when fed alone (B). The Δ(cydD-cydC) mutant exhibited a maintenance defect when mice were precolonized with E. coli EDL933 Δ(cydD-cydC) and challenged with wild-type E. coli EDL933 at day 10 (C).
