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. 2007 Jul 30;75(10):4933–4941. doi: 10.1128/IAI.00705-07

FIG. 5.

FIG. 5.

Immune serum can transfer protection against IOE challenge. a. Serum was pooled from immunized mice at least 30 days after infection and was administered to naïve mice 1 day prior and 3 and 7 days post-IOE challenge (100 μl/dose). Normal serum was administered as a control. Data combined from four experiments are shown (P = 0.0001; n = 17). The Ig titer of the immune sera was greater than 1:1,200. b. The monoclonal antibody Ec56.5, or an isotype control, was administered to naïve mice 1 day prior and 3 and 7 days post-IOE infection (200 μg/dose). Each group contained four mice. The data shown are representative of two experiments. c. Serum was pooled from E. muris-immunized MHC-II-deficient mice on day 30 postinfection and was administered to naive mice, as described for panel a. The differences were statistically significant (P < 0.0082; n = 5). The Ig titer of the immune serum was greater than 1:200.