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. 2007 Jul 30;75(10):4792–4798. doi: 10.1128/IAI.00587-07

FIG. 1.

FIG. 1.

Virulence studies with C. neoformans WT and Δgcs1 and reconstituted strains in Tgɛ26 mice, which are isogenic to CBA/J mice. (A) Mouse survival. The average survival times for Tgɛ26 mice infected with WT or Δgcs1+GCS1 were 17.2 ± 1.9 and 14.9 ± 2.4 days, respectively. Conversely, the Δgcs1-infected mice survived 58.5 ± 6.2 days (P < 0.001 †). (B) Mucicarmine staining of a lung obtained from a Tgɛ26 mouse infected with C. neoformans Δgcs1 for 36 days. Fungal cells (red) are contained within a nodular structure (black arrowheads) with a macrophage and granulocyte infiltration. The green arrow indicates normal lung tissue. Bar = 50 μm.