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Survival studies with Tgɛ26 mice receiving weekly doses of anesthesia alone, PBS, PBS-containing liposomes, or clodronate-containing liposomes. The mice were infected with C. neoformans WT or Δgcs1. While there is no significant difference among the different groups infected with C. neoformans WT, clodronate-treated mice survived an average of 76.6 ± 5.3 days (P < 0.05 †), which is significantly longer than the controls.
