FIG. 3.

Viable C. neoformans in internal organs of Tgɛ26 mice that were treated with PBS, PBS-containing liposomes, or clodronate-containing liposomes and infected intranasally with C. neoformans WT. No significant differences in the number of CFU were observed in lung (A), spleen (C), or kidney (D) homogenates at different time points after intranasal infection with C. neoformans WT. Clodronate-treated mice showed reductions in the tissue burden of C. neoformans WT in the brain (B) and in the spleen (C), but the differences were not statistically significant. The results are expressed as CFU per organ on a logarithmic scale.