Fig. 6. JNK inhibition enhances NFAT activation in vivo. (A) dnJNK1/2 mice were crossed with the transgenic NFAT indicator line and activity in the heart was assessed in 2-month-old mice at baseline or after 7 days of TAC stimulation (N = 4–6 mice in each group). (B) The increased NFAT activity correlated with the enhanced hypertrophic response to TAC in the same dnJNK1/2 transgenic mice as assessed by heart-to-body weight ratio HW/BW. (*P < 0.05 versus sham NFAT-Luc; †P < 0.05 versus NFAT indicator TG alone after TAC).