Figure 2.

Cells expressing ΔEGFR are diminished in their apoptotic response to CDDP. Cells were seeded on coverslips and treated with 5 μg/ml of CDDP for 2 days, and then TUNEL assays were performed. The percentage of TUNEL-positive cells induced by CDDP treatment was assessed by counting more than 400 cells per coverslip. □, U87MG; ▪, U87MG.ΔEGFR; ▨, U87MG.DK; ▧, U87MG.wtEGFR. Values represent means from three independent experiments, each performed in triplicate. ∗∗∗, Significantly different (P < 0.001) from the value for the U87MG.ΔEGFR cells treated with CDDP. (Bars = SE.)