Table 2.
Enriched cluster categories in region A: "Pezizomycotina abundant"
| Software or database | Database identifier | Category | Count of clusters in region | % of clusters in region | % of all clusters with category | P-value | Author assignment | Figure 13 |
| ProtFun | - | Enzyme/nonenzyme: Enzyme | 180 | 91.0 | 5 | 1.60E-11 | - | - |
| ProtFun | - | Enzyme class: Uncategorised | 147 | 74.0 | 6 | 1.60E-17 | - | - |
| ProtFun | - | Cellular role: Uncategorised | 143 | 72.0 | 4 | 2.10E-02 | - | - |
| Funcat | 01 | Metabolism | 81 | 41.0 | 6 | 8.00E-06 | Metabolism | - |
| ProtFun | - | TargetP: Uncategorised | 71 | 36.0 | 5 | 1.40E-04 | - | - |
| Funcat | 01.05 | C-compound and carbohydrate metabolism | 41 | 21.0 | 10 | 1.30E-07 | Plant biomass degradation | - |
| ProtFun | - | TargetP: Secretion | 39 | 20.0 | 9 | 1.30E-07 | - | - |
| ProtFun | - | Cellular role: Cell envelope | 30 | 15.0 | 11 | 1.20E-08 | - | - |
| Funcat | 01.05.01 | C-compound and carbohydrate utilization | 29 | 15.0 | 10 | 1.30E-05 | Plant biomass degradation | - |
| Funcat | 32 | Cell rescue, defence and virulence | 24 | 12.0 | 7 | 6.50E-03 | Virulence/Defence | - |
| Funcat | 01.05.01.01 | C-compound, carbohydrate catabolism | 22 | 11.0 | 22 | 4.40E-11 | Plant biomass degradation | - |
| ProtFun | - | TMHMM: Uncategorised | 20 | 10.0 | 7 | 3.70E-03 | - | - |
| Funcat | 01.20 | Secondary metabolism | 19 | 10.0 | 22 | 1.40E-09 | 2ary metabolism | - |
| Funcat | 32.05 | Disease, virulence and defence | 14 | 7.0 | 23 | 1.00E-07 | Virulence/Defence | - |
| Funcat | 01.05.01.01.02 | Polysaccharide degradation | 13 | 7.0 | 27 | 3.50E-08 | Plant biomass degradation | - |
| Funcat | 32.05.05 | Virulence, disease factors | 9 | 5.0 | 45 | 3.20E-08 | Virulence/Defence | - |
| Interpro | IPR001128 | Cytochrome P450 | 8 | 4.0 | 42 | 1.30E-07 | 2ary metabolism | YES |
| Interpro | IPR002347 | Glucose/ribitol dehydrogenase | 8 | 4.0 | 21 | 4.60E-05 | 2ary metabolism | YES |
| Funcat | 32.07 | Detoxification | 7 | 4.0 | 10 | 2.20E-02 | 2ary metabolism | - |
| Interpro | IPR002198 | Short-chain dehydrogenase/reductase SDR | 7 | 3.5 | 21 | 1.60E-04 | 2ary metabolism | YES |
| Interpro | IPR006094 | FAD linked oxidase, N-terminal | 5 | 2.5 | 56 | 6.30E-06 | 2ary metabolism | YES |
| Interpro | IPR003042 | Aromatic-ring hydroxylase | 5 | 2.5 | 36 | 8.60E-05 | 2ary metabolism | YES |
| Funcat | 01.25 | Extracellular metabolism | 4 | 2.0 | 36 | 7.30E-04 | Plant biomass degradation | - |
| Funcat | 02.16 | Fermentation | 4 | 2.0 | 20 | 8.00E-03 | Metabolism | - |
| Funcat | 01.05.01.01.01 | Sugar, glucoside, polyol and carboxylate catabolism | 4 | 2.0 | 19 | 9.50E-03 | Plant biomass degradation | - |
| Funcat | 30.05 | Transmembrane signal transduction | 4 | 2.0 | 12 | 4.50E-02 | Signalling | - |
| Interpro | IPR011050 | Pectin lyase fold/virulence factor | 4 | 2.0 | 27 | 1.60E-03 | Plant biomass degradation | NO |
| Interpro | IPR000873 | AMP-dependent synthetase and ligase | 4 | 2.0 | 25 | 2.10E-03 | 2ary metabolism | YES |
| Interpro | IPR008985 | Concanavalin A-like lectin/glucanase | 4 | 2.0 | 24 | 2.60E-03 | Plant biomass degradation | NO |
| Funcat | 32.10.07 | Degradation of foreign (exogenous) polysaccharides | 3 | 2.0 | 50 | 1.20E-03 | Plant biomass degradation | - |
| Funcat | 01.01.09.05 | Metabolism of tyrosine | 3 | 2.0 | 43 | 2.10E-03 | 2ary metabolism | - |
| Funcat | 01.05.01.01.09 | Aerobic aromate catabolism | 3 | 2.0 | 43 | 2.10E-03 | Metabolism | - |
| Funcat | 32.10 | Degradation of foreign (exogenous) compounds | 3 | 2.0 | 38 | 3.30E-03 | Plant biomass degradation | - |
| Funcat | 02.25 | Oxidation of fatty acids | 3 | 2.0 | 27 | 8.80E-03 | 2ary metabolism | - |
| Interpro | IPR010730 | Heterokaryon incompatibility | 3 | 1.5 | 75 | 1.80E-04 | Mating | YES |
| Interpro | IPR003661 | Histidine kinase A, N-terminal | 3 | 1.5 | 43 | 1.40E-03 | Signalling | NO |
| Interpro | IPR006163 | Phosphopantetheine-binding | 3 | 1.5 | 43 | 1.40E-03 | 2ary metabolism | YES |
| Interpro | IPR005467 | Histidine kinase | 3 | 1.5 | 38 | 2.20E-03 | Signalling | NO |
| Interpro | IPR001789 | Response regulator receiver | 3 | 1.5 | 33 | 3.20E-03 | Signalling | NO |
| Funcat | 30.05.01.10 | Two-component signal transduction system | 2 | 1.0 | 67 | 4.90E-03 | Signalling | - |
| Funcat | 32.05.05.01 | Toxins | 2 | 1.0 | 50 | 9.50E-03 | 2ary metabolism | - |
| Funcat | 01.01.09.05.02 | Degradation of tyrosine | 2 | 1.0 | 40 | 1.50E-02 | 2ary metabolism | - |
| Funcat | 01.20.37 | Biosynthesis of peptide derived compounds | 2 | 1.0 | 40 | 1.50E-02 | 2ary metabolism | - |
| Funcat | 34.11.11 | Rhythm (e.g. circadian, ultradian) | 2 | 1.0 | 40 | 1.50E-02 | Other | - |
| Funcat | 01.01.09.04 | Metabolism of phenylalanine | 2 | 1.0 | 33 | 2.30E-02 | 2ary metabolism | - |
| Funcat | 01.25.01 | Extracellular polysaccharide degradation | 2 | 1.0 | 33 | 2.30E-02 | Plant biomass degradation | - |
| Funcat | 16.05 | Polysaccharide binding | 2 | 1.0 | 33 | 2.30E-02 | Plant biomass degradation | - |
| Funcat | 16.21.05 | FAD/FMN binding | 2 | 1.0 | 33 | 2.30E-02 | 2ary metabolism | - |
| Funcat | 01.01.11.03.02 | Degradation of valine | 2 | 1.0 | 29 | 3.10E-02 | 2ary metabolism | - |
| Funcat | 30.05.01 | Receptor enzyme mediated signalling | 2 | 1.0 | 25 | 4.00E-02 | Signalling | - |
| Funcat | 01.20.35.01 | Biosynthesis of phenylpropanoids | 2 | 1.0 | 22 | 5.00E-02 | 2ary metabolism | - |
| Interpro | IPR000675 | Cutinase | 2 | 1.0 | 100 | 1.30E-03 | Plant biomass degradation | NO |
| Interpro | IPR001077 | O-methyltransferase, family 2 | 2 | 1.0 | 100 | 1.30E-03 | Regulation | NO |
| Interpro | IPR002227 | Tyrosinase | 2 | 1.0 | 100 | 1.30E-03 | 2ary metabolism | NO |
| Interpro | IPR008922 | Di-copper centre-containing | 2 | 1.0 | 100 | 1.30E-03 | Dubious | NO |
| Interpro | IPR012951 | Berberine/berberine-like | 2 | 1.0 | 100 | 1.30E-03 | 2ary metabolism | NO |
| Interpro | IPR000743 | Glycoside hydrolase, family 28 | 2 | 1.0 | 67 | 3.70E-03 | Plant biomass degradation | NO |
| Funcat | 01.05.01.01.11 | Anaerobic aromate catabolism | 1 | 1.0 | 100 | 4.10E-02 | Metabolism | - |
| Funcat | 01.20.01.09 | Biosynthesis of aminoglycoside antibiotics | 1 | 1.0 | 100 | 4.10E-02 | 2ary metabolism | - |
| Funcat | 01.20.23 | Biosynthesis of secondary products derived from L-methionine | 1 | 1.0 | 100 | 4.10E-02 | 2ary metabolism | - |
| Funcat | 01.20.36 | Non-ribosomal peptide synthesis | 1 | 1.0 | 100 | 4.10E-02 | 2ary metabolism | - |
| Funcat | 01.20.37.05 | Biosynthesis of beta-lactams | 1 | 1.0 | 100 | 4.10E-02 | 2ary metabolism | - |
| Funcat | 02.16.03.03 | Heterofermentative pathway and fermentation of other saccharides | 1 | 1.0 | 100 | 4.10E-02 | Metabolism | - |
| Funcat | 32.05.05.03 | Bacteriocins | 1 | 1.0 | 100 | 4.10E-02 | 2ary metabolism | - |
| Funcat | 32.07.09 | Detoxification by degradation | 1 | 1.0 | 100 | 4.10E-02 | 2ary metabolism | - |
| Funcat | 34.11.01.01 | Light environment response | 1 | 1.0 | 100 | 4.10E-02 | Signalling | - |
| Funcat | 36.20.18 | Plant hormonal regulation | 1 | 1.0 | 100 | 4.10E-02 | Signalling | - |
Software or database that the categories were derived from, category database identifier, category name, count of clusters with the category, percentage of all clusters in this region, percentage of all clusters with the category and significance of enrichment are shown for categories which are enriched in the region (Figure 4) with a p < 0.01. Column "Author assignment" shows an assignment to general themes, based on the respective database, that summarise the InterPro and Funcat categories. While the other assignments are directly based on the databases, "Secondary metabolism" covers entries which are known to participate also in secondary metabolism ([61, 62], Funcat and InterPro). For InterPro entries whether the entry is found from Figure 9 is specified in column "Figure 9". InterPro entries assigned to "Dubious" are entries that InterPro itself considers unreliable.