Table 2.

Enriched GOTERM Cellular Component in the list of differentially expressed genes at 4 h after HAL-PDT

GOTERM Cellular Component (level 5)	Gene Count	%	P-Value*
Total/Down regulated gene list
mitochondrion	418/345	4.1	1.1E-17
mitochondrial envelope	124/104	1.2	2.2E-07
nuclear lumen	230/196	2.2	3.5E-07
mitochondrial membrane	113/94	1.1	1.3E-06
nucleus	2001/1390	19.5	1.3E-06
mitochondrial inner membrane	95/77	0.9	2.4E-06
mitochondrial lumen	56/50	0.5	7.7E-06
ribosome	223/200	2.2	0.000023
nucleolus	74/69	0.7	0.000035
large ribosomal subunit	41/34	0.4	0.00026
nucleoplasm	157/128	1.5	0.00062
cytosolic ribosome (sensu Eukaryota)	32/29	0.3	0.0007
mitochondrial electron transport chain	32/22	0.3	0.0007
cytosolic large ribosomal subunit (sensu Eukaryota)	23/20	0.2	0.00074
organellar ribosome	23/20	0.2	0.0018
mitochondrial ribosome	23/20	0.2	0.0018
heterogeneous nuclear ribonucleoprotein complex	15/15	0.1	0.0021
spliceosome complex	44/39	0.4	0.0039
small nucleolar ribonucleoprotein complex	21/21	0.2	0.0046
endoplasmic reticulum lumen	15/14	0.1	0.0063
proton-transporting ATP synthase complex (sensu Eukaryota)	12/9	0.1	0.011
endoplasmic reticulum	291/219	2.8	0.015
small nuclear ribonucleoprotein complex	13/13	0.1	0.017
proton-transporting two-sector ATPase complex	35/26	0.3	0.018
organellar small ribosomal subunit	12/11	0.1	0.029
endoplasmic reticulum membrane	55/47	0.5	0.035
Up-regulated gene list
integral to plasma membrane	297	6.0	1.4E-06
intercellular junction	32	0.6	0.035
nucleosome	20	0.4	0.041
chromatin	38	0.8	0.044
actin cytoskeleton	47	0.9	0.14
nucleus	752	15.2	0.16
microsome	31	0.6	0.18
cytoskeleton	175	3.5	0.22
apical junction complex	15	0.3	0.33
microtubule associated complex	24	0.5	0.37
mitochondrial electron transport chain	10	0.2	0.4

*The gene-enrichment of functional categories was measured by determining the number of genes, belonging to the functional group in the list of modulated genes weigh against to the total analysed genes on arrays (background) using Fisher Exact test.