Table 4.

Enriched GOTERM Biological Process in the list of alternatively spliced genes

Up-regulated splice variants, with fold change [≥1] at 4 h	Gene Count	%	P-Value*
regulation of protein metabolism	5	5.7	0.029
cellular protein metabolism	24	27.3	0.041
phosphate metabolism	9	10.2	0.097
cytoskeleton organization and biogenesis	5	5.7	0.16
RNA metabolism	5	5.7	0.23
biopolymer modification	12	13.6	0.27
macromolecule biosynthesis	6	6.8	0.49
Down regulated splice variants, with fold change [≥1] at 4 h
cellular lipid metabolism	15	6.4	0.0094
negative regulation of cellular metabolism	8	3.4	0.035
membrane lipid metabolism	6	2.6	0.042
regulation of progression through cell cycle	13	5.5	0.044
intracellular transport	15	6.4	0.058
biopolymer modification	33	14.0	0.06
establishment of cellular localization	15	6.4	0.063
DNA metabolism	15	6.4	0.073
amino acid metabolism	8	3.4	0.073
protein catabolism	7	3.0	0.1
intracellular protein transport	9	3.8	0.1
biopolymer catabolism	7	3.0	0.13
regulation of protein kinase activity	5	2.1	0.15
carboxylic acid metabolism	11	4.7	0.15
endocytosis	5	2.1	0.17
cofactor biosynthesis	5	2.1	0.18
steroid metabolism	5	2.1	0.18
negative regulation of cell proliferation	5	2.1	0.2
lipid biosynthesis	6	2.6	0.22
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism	37	15.7	0.26
apoptosis	11	4.7	0.31
transcription	37	15.7	0.33
cellular macromolecule catabolism	7	3.0	0.36
protein complex assembly	6	2.6	0.4
protein transport	10	4.3	0.44
chromosome organization and biogenesis	6	2.6	0.44
vesicle-mediated transport	7	3.0	0.45
synaptic transmission	5	2.1	0.46

*The gene-enrichment of functional categories was measured by determining the number of genes, belonging to the functional group in the list of modulated genes weigh against to the total analysed genes on arrays (background) using Fisher Exact test.