TABLE 2.
Performance of tests for diagnosing pulmonary aspergillosis
| Test and cutoff | Sensitivity (%) (no. of positive samples/total no. of samples) (range) | Specificity (%) (no. of positive samples/total no. of samples) (range) | PPV (%) (no. of positive samples/total no. of samples) (range) | NPV (%) (no. of positive samples/total no. of samples) (range) |
|---|---|---|---|---|
| BAL GM | ||||
| ≥0.5 | 100 (6/6) (54.1-100) | 77.6 (52/67) (65.8-86.9) | 28.6 (6/21) (11.3-52.2) | 100 (52/52) (93.2-100) |
| ≥1.0 | 100 (6/6) (54.1-100) | 88.1 (59/67) (77.8-94.7) | 42.9 (6/14) (17.1-71.1) | 100 (59/59) (93.9-100) |
| ≥1.5 | 66.7 (4/6) (22.3-95.7) | 91 (61/67) (81.5-96.6) | 40 (4/10) (12.2-73.8) | 96.8 (61/63) (89.3-99.6) |
| ≥2.0 | 66.7 (4/6) (22.3-95.7) | 94 (63/67) (85.4-98.4) | 50 (4/8) (15.7-84.3) | 96.9 (63/65) (89.3-99.6) |
| ≥2.5 | 50 (3/6) (11.8-88.2) | 95.5 (64/67) (87.5-99.1) | 50 (3/6) (11.8-88.2) | 95.5 (64/67) (87.5-99.1) |
| Serum GMa | ||||
| ≥0.5 | 60 (3/5) (14.7-94.7) | 91.7 (11/12) (61.5-99.8) | 75 (3/4) (19.4-99.4) | 84.6 (11/13) (54.6-98.1) |
| ≥1.0 | 40 (2/5) (5.3-85.3) | 91.7 (11/12) (61.5-99.8) | 66.7 (2/3) (9.4-99.2) | 78.6 (11/14) (49.2-95.4) |
| BAL culture | 66.7 (4/6) (22.3-95.7) | 94 (63/67) (85.4-98.4) | 50 (4/8) (15.7-84.3) | 96.9 (63/65) (89.3-99.6) |
| BAL microscopyb | 80 (4/5) (28.4-99.5) | 96.9 (63/65) (89.3-99.6) | 66.7 (4/6) (22.3-95.7) | 98.4 (63/64) (91.6-100) |
| BAL culture or microscopy | 100 (6/6) (54.1-100) | 92.5 (62/67) (83.4-97.5) | 54.5 (6/11) (23.4-83.2) | 100 (62/62) (94.2-100) |
a
The serum GM test was performed for only 17 patients.
b
BAL microscopy was performed for only 70 patients.