TABLE 1.
General characteristics and mutations in the atpC gene coding for the c subunit of F0 F1 ATPase in Optr S. pneumoniae isolates
| Isolate | Serotype or serogroup | Location of mutationa | Locality of isolation | Resistance to antimicrobial agentsb | Genetic relatedness among strains in the study | Reference |
|---|---|---|---|---|---|---|
| MJ9559 | 19 | 49 (Ala→Thr) | Spain | NP/NRc | NP/NR | 7 |
| MJ455 | 6 | 48 (Val→Phe) | Spain | NP/NR | ||
| MJ1966 | 14 | 50 (Phe→Leu) | Spain | NP/NR | ||
| MJ4133 | NTd | 48 (Val→Phe) | Spain | NP/NR | ||
| P21 | 23 | 14 (Gly→Ser) | France | NP/NR | NAe | 6 |
| 310 | 9V | 23 (Met→Ile) | United States | None | Unrelated | 13 |
| 660 | 14 | 49 (Ala→Thr) | United States | None | PFGE profiles | |
| 654 | 19F | 20 (Gly→Ser) | United States | CHL, PEN | ||
| Sp 910 | 6A | 23 (Met→Ile) | Brazil | CHL, SXT | Unrelated | Present |
| Sp 913 | 23F | 49 (Ala→Ser) | Brazil | None | PFGE profiles | study |
| Sp 917 | 6B | 45 (Phe→Leu) | Brazil | None | ||
| Sp 1008 | 10A | 45 (Phe→Val) | Brazil | TET |
a
Codon no. (amino acid found in Opts S. pneumoniae R6 reference strain → deduced amino acid substitution found in the isolate being referred).
b
CHL, chloramphenicol; PEN, penicillin; SXT, sulfamethoxazole-trimethoprim; TET, tetracycline.
c
NP/NR, not performed or not reported.
d
NT, nontypable.
e
NA, not applicable.