TABLE 2.
PCR assay results from a combined cohort of 264 subjects analyzing the utility of each assay for the diagnosis of BV, with Amsel clinical criteria used to define BVa
| Bacterium | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | OR (95% CI) |
|---|---|---|---|
| BVAB1 | 43.2 (33.0-54.1) | 96.7 (93.0-98.5) | 22.45 (8.90-56.6) |
| BVAB2 | 86.4 (77.3-92.2) | 92.9 (88.2-95.8) | 83.2 (35.6-195) |
| BVAB3 | 42.0 (31.8-52.9) | 96.7 (93.0-98.5) | 21.3 (8.5-53.9) |
| G. vaginalis | 96.3 (89.7-98.7) | 29.5 (23.4-36.5) | 10.9 (3.3-36.0) |
| Atopobium spp. | 96.3 (89.7-98.7) | 77.05 (70.4-82.6) | 87.3 (26.2-291) |
| Eggerthella-like bacterium | 91.4 (83.2-95.8) | 86.3 (80.6-90.6) | 66.8 (27.65-162) |
| Leptotrichia spp. | 82.7 (73.1-89.4) | 89.1 (83.7-92.8) | 39.0 (18.6-81.7) |
| Megasphaera phylotype 1 | 95.1 (88.0-98.1) | 88.5 (83.1-92.4) | 148.5 (49.3-448) |
| Megasphaera phylotype 2 | 18.5 (11.6-28.3) | 98.9 (96.1-99.7) | 20.6 (4.6-92.4) |
| Either Megasphaera sp. | 97.5 (91.4-99.3) | 88.5 (83.1-92.4) | 305 (69.7-1,332) |
| BVAB-TM7 | 33.3 (24.0-44.2) | 97.8 (94.5-99.2) | 22.4 (7.5-66.8) |
| M. curtisii | 55.6 (44.7-65.9) | 92.9 (88.2-95.8) | 16.3 (8.0-33.4) |
| M. mulieris | 22.2 (14.5-32.4) | 100 (97.9-100) | Infinity |
| Either Mobiluncus sp. | 65.4 (54.6-74.9) | 92.9 (88.2-95.8) | 24.8 (12.0-51.2) |
| Peptoniphilus sp. type 1 | 83.8 (74.1-90.3) | 70.0 (63.0-76.1) | 12.0 (6.1-23.5) |
| Peptoniphilus lacrimalis | 70.4 (59.7-79.2) | 78.1 (71.6-83.5) | 8.5 (4.7-15.4) |
| Either Peptoniphilus sp. | 88.9 (80.2-94.0) | 60.7 (53.4-67.4) | 12.3 (5.8-26.2) |
| Prevotella G1 | 63.8 (52.8-73.4) | 94.0 (89.6-96.6) | 27.5 (12.9-58.9) |
| L. crispatus | 16.1 (9.6-25.6) | 10.4 (6.8-15.7) | 0.022 (0.01-0.05) |
| L. iners | 98.8 (93.3-99.8) | 8.8 (5.5-13.7) | 7.7 (1.0-58.8) |
| Either BVAB1 or BVAB2 | 87.7 (78.7-93.2) | 92.9 (88.2-95.8) | 92.8 (38.9-222) |
| Either BVAB1 or BVAB3 | 48.2 (37.6-58.9) | 95.1 (90.9-97.4) | 18.0 (8.1-39.9) |
| Either BVAB2 or BVAB3 | 87.7 (78.7-93.2) | 92.9 (88.2-95.8) | 92.8 (38.9-222) |
| Either BVAB1, -2, or -3 | 87.7 (78.7-93.2) | 92.9 (88.2-95.8) | 92.8 (38.9-222) |
| Either Megasphaera phylotype 1 or BVAB2 | 98.8 (93.3-99.8) | 88.5 (83.1-92.4) | 617 (81.6-4,670) |
a
The analysis consisted of 81 subjects with BV and 183 subjects without BV.