TABLE 6.
Samples resulting in different disease state classifications between DRL and this study
Specimen | PRNT90a
|
P/N valueb
|
Antigenc | Disease state classificationd | |||||
---|---|---|---|---|---|---|---|---|---|
IgM
|
IgG
|
||||||||
SLEV | WNV | DENV-2 | SLEV | WNV | SLEV | WNV | |||
57 | 40 | 40 | 1.50 | 5.31 | 4.98 | 4.23 | DRL | Flavivirus | |
14.56 | 1.10 | NDe | ND | WT | SLEV | ||||
5.00 | 1.09 | ND | ND | Mutant | |||||
98 | 20 | 40 | 3.50 | 5.50 | 6.80 | 4.30 | DRL | Flavivirus | |
7.69 | 10.11 | ND | ND | WT | WNV | ||||
1.14 | 3.73 | ND | ND | Mutant | |||||
103 | 5120 | 2560 | 5.90 | 5.00 | 7.60 | 15.50 | DRL | Flavivirus | |
5.29 | 7.11 | ND | ND | WT | WNV-secondary | ||||
4.71 | 4.91 | ND | ND | Mutant | |||||
109 | <10 | <10 | 1.20 | 2.70 | 4.60 | 4.60 | DRL | Recent WNV | |
5.71 | 2.55 | ND | ND | WT | Unknown flavivirus | ||||
1.77 | 1.93 | ND | ND | Mutant | |||||
115 | 20 | 160 | 0.85 | 2.50 | 3.60 | 8.20 | DRL | Recent WNV | |
1.03 | 2.72 | ND | ND | WT | Unknown etiology | ||||
1.06 | 2.41 | ND | ND | Mutant | |||||
62 | <10 | <10 | 10 | 1.79 | 1.18 | 5.71 | 1.95 | DRL | Recent SLEV |
1.59 | 1.43 | ND | ND | WT | Unknown etiology | ||||
1.12 | 1.31 | ND | ND | Mutant | |||||
34 | 2560 | 640 | 6.90 | ND | 3.60 | 4.10 | DRL | Flavivirus | |
1.93 | 1.37 | ND | ND | WT | Unknown etiology | ||||
1.95 | 1.43 | ND | ND | Mutant | |||||
42 | 20480 | 1280 | 3.90 | 2.00 | 10.50 | 3.20 | DRL | SLEV | |
1.14 | 1.74 | ND | ND | WT | Unknown etiology | ||||
1.18 | 2.03 | ND | ND | Mutant | |||||
93 | <10 | 10 | 40 | 1.44 | 2.07 | 2.49 | 3.27 | DRL | Flavivirus, WNV-secondary |
1.08 | 1.14 | ND | ND | WT | Unknown etiology | ||||
0.99 | 1.10 | ND | ND | Mutant | |||||
58 | 20 | 10 | 20 | 2.53 | 4.72 | 8.11 | 7.00 | DRL | Flavivirus |
1.19 | 1.19 | ND | ND | WT | Unknown etiology | ||||
1.14 | 0.99 | ND | ND | Mutant | |||||
59 | ND | ND | 2.80 | 6.52 | 9.03 | 8.00 | DRL | Flavivirus | |
1.08 | 1.55 | ND | ND | WT | Unknown etiology | ||||
0.85 | 1.06 | ND | ND | Mutant |
PRNT90, titers represent 90% plaque reduction endpoints reported by the DRL.
P/N values of ≥3.0 are shown in boldface.
ELISA data are presented from tests with three types of antigen: the DRL antigens, which include both SMB and VLP for WNV and SMB for SLEV; this study's WT VLP antigens; and the mutant antigens with reduced cross-reactivity of both WNV and SLEV.
DRL disease state classifications are matched by row with the DRL antigen. Some of the DRL disease state classifications are based partially on additional data not presented in this table.
ND, not done.