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Bortezomib inhibits activation of p50 and p65. LCLa cells were cultured in the absence or presence of 1 μM bortezomib for 4 h, nuclear extracts were prepared, and electrophoretic mobility shift assays were performed with a radiolabeled NF-κB probe in the presence of preimmune rabbit sera or rabbit antibody to p50 or p65. Numbers below the autoradiogram show intensities of p65:p50 heterodimer and p50:p50 homodimer bands assayed by densitometry.
