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C-terminal mutations of ORF6 affect karyopherin localization. (A) HA-tagged alanine scanning mutants of ORF6 (as described in the text) were cotransfected with either Flag-tagged KPNA1 or KPNA2. At 24 h posttransfection, cells were fixed and labeled with anti-HA and anti-Flag antibodies. Cells were visualized using a confocal microscope for Alexa Fluor 488 and Alexa Fluor 546 fluorescence.
