FIG. 6.

Cells expressing viral antigens had a propensity for increased metastases in the lung. (a to f) H&E-stained lung sections show tumor foci formed due to metastasis of cancer cells from site of primary injection. The sections of lungs stained with H&E are shown for each experimental group. (g and h) Lung sections were stained with anti-cytokeratin 19 antibody to detect micrometastases. (i to k) The metastasis potential of cancer cells, as represented by the relative count of metastasis foci in lungs of mice observed after histopathology in different groups of mice, is shown in the bottom panels. The differences in metastatic foci count in mice injected with EBV antigens were significantly higher than in those injected with vector control, as shown by P values above the bars.