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. Author manuscript; available in PMC: 2008 Sep 1.
Published in final edited form as: J Mol Cell Cardiol. 2007 Jun 6;43(3):281–291. doi: 10.1016/j.yjmcc.2007.05.022

Fig. 5.

Fig. 5

Effect of isoproterenol on Ca2+ release kinetics in isolated hearts. Release kinetic was measured following the change in fluorescence of Calcium Green 5 and was fitted to the double exponential function: A1 [1−exp (−k1t)]+A2 [1−exp (−k2t)]. Representative Ca2+ release records in SR vesicles isolated from hearts submitted to the different experimental protocols. The increase in Ca2+ release kinetics produced by isoproterenol (Iso, A) was significantly decreased bylow [Ca]o plus nifedipine (Iso-low Ca, B) or by CaMKII-inhibition (Iso-KN, C). Records shown are the average of 5 to 7 determinations.