FIG. 5.
Protective efficacy of M2-181-89 and N307-315 CD8+ T cells. HMPV titers in lungs of Rag1−/− mice were determined 4 days after i.n. challenge with 106 PFU of wild-type hMPV. Rag1−/− mice received 7 × 106 T cells specific for M2-181-89 or N307-315 epitopes by passive transfer 24 h prior to challenge. Control groups of Rag1−/− mice received cells specific for an irrelevant control peptide (Y26 from P. berghei) or no cells before hMPV infection. Four to five mice per group were used. The results are means ± SEM and are representative of two independent experiments.