TABLE 1.
Effect of AG110 on the in vitro replication of various members of the family of the Flaviviridae
| Virus | Strain or genotype | Biotype | EC50 (μM) of AG110 as determined by:a
|
||||
|---|---|---|---|---|---|---|---|
| CPE assay | IHC assay | RNA yield | Virus yield | Luciferase assay | |||
| BVDV-1 | Marloie | ncp | 5.9 ± 0.9 | ||||
| NADL | cp | 1.2 ± 0.5 | 7 ± 1 | 5 ± 1 | 2.3 ± 0.3 | ||
| BVDV-2 | 3435 | ncp | 19 ± 0 | ||||
| CSFV | Alfort | 10 ± 6 | |||||
| BDV | Aveyron | 6 ± 1 | |||||
| HCV | 1b | >50 | |||||
| YFV | 17D | >50 | |||||
a
The EC50 for inhibition of viral replication was assessed by either a CPE reduction assay, an immunohistochemical (IHC) assay, an RNA or virus reduction assay, and a luciferase assay for the virus strains indicated. Data are mean values ± standard deviations for three or more independent experiments.