TABLE 4.
Frequency of rAAV labeling of DNA palindromes with an arm length of ≥20 bp in the presence or absence of DNA-PKcs activitya
| Mouse group by AAV serotype, tissue type, and vector dose | No. of rAAV labeling events in each category
|
χ2 Value | P value (d = 1) | ||
|---|---|---|---|---|---|
| Palindromes (arm length, ≥20 bp) | Other sites | Total | |||
| AAV8/Lv/lo | |||||
| B6 | 18 | 183 | 201 | 0.76 | 0.39 |
| SCID | 8 | 55 | 63 | ||
| AAV2/Lv/lo | |||||
| B6 | 15 | 61 | 76 | 2.06 | 0.15 |
| SCID | 9 | 70 | 79 | ||
| AAV8/H/hi | |||||
| B6 | 15 | 68 | 83 | 3.19 | 0.07 |
| SCID | 27 | 64 | 91 | ||
a
Abbreviations: Lv, liver; H, heart; B6, DNA-PKcs-proficient C57BL/6J mice; SCID, DNA-PKcs-deficient C57BL/6J mice; hi, high vector dose; lo, low vector dose; d, degree of freedom.