TABLE 2.
Virus titers in TG and brains at different time points p.i.a
| Mouse group | Virus titer (log10 PFU/ml)
|
|||
|---|---|---|---|---|
| Day 4 p.i.
|
Day 7 p.i.b
|
|||
| TG | Brain | TG | Brain | |
| WT | 3.2 ± 0.04 | 1.7 ± 0.29 | UD | UD |
| TLR9−/− | 3.7 ± 0.08 | 2.3 ± 0.2 | UD | UD |
| TLR2−/− | 3.2 ± 0.03 | 2.3 ± 0.07 | UD | UD |
| MyD88−/− | 3.7 ± 0.06 | 2.2 ± 0.20 | UD | 3.8 ± 0.30c |
a
Mice were infected with 3 × 105 PFU of HSV-1 RE and killed on day 4 or day 7 to measure viral titers, using a standard plaque assay, in brain and TG homogenates (n = 3).
b
UD, undetected, i.e., below the sensitivity of the assay (<10 PFU/ml).
c
Virus was also detected in brain tissues collected from dying MyD88−/− mice (days 10 to 15).