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. 2007 Nov 1;117(11):3339–3349. doi: 10.1172/JCI31726

Figure 2. Systemic steroid-induced downregulation of epidermal AMPs mimics effects of PS.

Figure 2

Cohorts of normal hairless mice (n = 3 per cohort) received intraperitoneal dexamethasone (dex; 450 μg/cell/kg daily for 3 d, C and F) or vehicle alone (daily for 3 d, B and E) or were left untreated (A and D). Biopsies were obtained for immunostaining for CRAMP and mBD3 (see Methods). Scale bar: 50 μm.