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. 2007 Nov 1;117(11):3421–3426. doi: 10.1172/JCI32430

Figure 3. Quantitative real-time PCR gene expression analysis of macrophage-rich lesions from young and old mouse eyes after laser injury.

Figure 3

Matching unlasered tissue was used as the baseline control. Macrophages from old mice demonstrated significant (asterisks) downregulation of IL-12 (A, P = 0.0068627), TNF-α (B, P = 0.0370), and FasL (C, P = 0.0302) compared with young mice. IL-6 (D, P = 0.00017) and IL-23 (E, P = 0.1024) were upregulated at levels exponentially higher in young mice than in old mice. (F) IL-10 was upregulated in both young and old mice, although baseline levels of IL-10 (P = 0.0701) were significantly higher in old mice than young mice. RQ, relative quantification.