Matching unlasered tissue was used as the baseline control. (A–D) Macrophages from IL-10–/– mice demonstrated upregulation of IL-6 (A, P = 0.0558), TNF-α (B, P = 0.3579), IL-12 (C, P = 0.1824), and FasL (D, P = 0.4569) compared with young mice. (E) IL-10 was upregulated in young mice and deficient in IL-10–/– mice. *P = 0.0513.