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. Author manuscript; available in PMC: 2008 Jul 18.
Published in final edited form as: Int J Pharm. 2007 Mar 6;339(1-2):246–250. doi: 10.1016/j.ijpharm.2007.02.033

Figure 1. ATRA-ND formulation scheme and structure model.

Figure 1

Phospholipid vesicles, ATRA and apoE3-NT (as a lipid-free 4-helix bundle; Wilson et al., 1991) were combined to form ATRA-ND. Lipid interaction converts apo E3-NT from a soluble 4-helix bundle into an open, extended lipid bound conformation (Narayanaswami et al., 2004). ATRA ND are comprised of a disk-shaped phospholipid bilayer in which ATRA molecules (yellow dots) are integrated. The edge of the ND bilayer is stabilized by the apolipoprotein “scaffold”. Component images are not to scale.