FIGURE 3. Rate of lipid absorption in mice.

Mice consuming a high fat/ high cholesterol diet were fasted for 14 h, then given Poloxamer 407 via intraperitoneal injection (1 g/kg of body weight). After 15 min mice were given [¹⁴C]triolein and [³H]retinyl palmitate in olive oil (A and B) or [¹⁴C]cholesteryl oleate and [³H]retinyl palmitate in phospholipid vesicles (C and D). The appearance of radiolabel derived from triacylglycerol (A), retinyl ester (B and C), or cholesteryl ester (D) in the circulation at the indicated times after delivery of the bolus meal was determined by scintillation counting. The data are shown as the means ± S.E. for n = 8 wild type (•), 7 PTL^−/− (○), 11 CEL^−/− (▼ ), and 8 PTL−/−,CEL−/− (▽) mice for A and B, and n = 9 wild type (•), 7 PTL^−/−(○), 7 CEL(−/−) (▼ ), and 9 PTL^−/−,CEL^−/− (▽) mice for C and D.*, p < 0.05; **, p < 0.01; ***, p < 0.001 (differences from wild type mice).