Table 4.
Mean Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, and Body Weight at Baseline and Final Visit for Each Disordera
| SWSD |
OSA |
Narcolepsy |
|||||
|---|---|---|---|---|---|---|---|
| Modafinil | PL | Modafinil | PL | Modafinil | PL | ||
| Parameter | Time Point | n = 273 | n = 194 | n = 292 | n = 188 | n = 369 | n = 185 |
| Heart rate, bpm | Baseline | 71.1 (9.9) | 69.9 (8.8) | 72.4 (10.2) | 71.1 (9.9) | 75.3 (11.4) | 74.1 (11.0) |
| Final visit | 71.5 (10.3) | 70.3 (9.9) | 72.2 (10.0) | 71.3 (10.8) | 75.4 (10.4)b | 73.3 (10.4) | |
| Blood pressure, mm Hg | |||||||
| Systolic | Baseline | 122.6 (13.1) | 121.9 (12.3) | 126.9 (12.7) | 129.5 (12.3) | 122.5 (16.4) | 121.0 (15.4) |
| Final visit | 123.9 (13.3) | 123.3 (13.8) | 126.6 (12.7) | 127.4 (12.3) | 121.3 (15.5)b | 118.0 (15.4) | |
| Diastolic | Baseline | 77.9 (9.6) | 79.0 (9.1) | 80.0 (8.0) | 80.4 (8.3) | 76.0 (10.6) | 75.5 (9.9) |
| Final visit | 77.9 (9.8) | 78.4 (8.9) | 79.3 (8.5) | 78.8 (8.4) | 75.4 (10.7) | 74.6 (10.2) | |
| Body weight, kg | Baseline | 89.6 (20.9) | 87.3 (16.8) | 109.7 (22.8) | 109.7 (24.2) | 84.2 (19.6) | 83.2 (19.2) |
| Final visit | 88.6 (21.0) | 87.3 (16.9) | 108.8 (23.4) | 109.9 (24.2) | 83.9 (19.6) | 84.2 (19.3) | |
bpm refers to beats per minute; OSA, obstructive sleep apnea; PL, placebo; SWSD, shift work sleep disorder.
a
All values are number (SD).
b
p < .05 vs placebo.