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. Author manuscript; available in PMC: 2008 Oct 15.
Published in final edited form as: Biochem Pharmacol. 2007 Jun 22;74(8):1315–1319. doi: 10.1016/j.bcp.2007.06.026

Figure 3. Effects of overexpression of SLURP-1 and -2 on the tumorigenic activity of NNK in Het-1A cells.

Figure 3

Intact Het-1A cells or the cells transfected with either control or SLURP-1 or -2 vectors were preincubated for 24 h with 1 μM of NNK, after which their tumorigenic activities were measured in vitro and in vivo as detailed in Methods. Asterisks indicate significant (p<0.05) differences compared to results obtained using intact Het-1A cells exposed to NNK. Pound sign indicates p=0.05.

A, Overexpression of SLURP-1 or -2 in each case reduces numbers of colonies in soft agar produced by nitrosamine-treated Het-1A cells.

B, Overexpression of SLURP-1 or -2 in each case reduces number of tumor nodules