Skip to main content
PMC home page
The American Journal of Pathology logoLink to The American Journal of Pathology
. 1970 Nov;61(2):275–292.

Uncommon morphologic features in subacute sclerosing panencephalitis (SSPE). Report of two cases with virus recovery from one autopsy brain specimen.

J C Parker Jr, G K Klintworth, D G Graham, J F Griffith
PMCID: PMC2047387  PMID: 5483589

Full text

PDF

Images in this article

286Fig 3
on p.286
286Fig 4
on p.286
288Fig 7
on p.288
288Fig 8
on p.288
289Fig 9
on p.289
289Fig 10
on p.289
291Fig 13
on p.291
291Fig 14
on p.291
291Fig 15
on p.291
287Fig 5
on p.287
287Fig 6
on p.287
285Fig 1
on p.285
285Fig 2
on p.285
290Fig 11
on p.290
290Fig 12
on p.290

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CORSELLIS J. A. N. Sub-acute sclerosing leuco-encephalitis: a clinical and pathological report of two cases. J Ment Sci. 1951 Jul;97(408):570–583. doi: 10.1192/bjp.97.408.570. [DOI] [PubMed] [Google Scholar]
  2. Chen T. T., Watanabe I., Zeman W., Mealey J., Jr Subacute sclerosing panencephalitis: propagation of measles virus from brain biopsy in tissue culture. Science. 1969 Mar 14;163(3872):1193–1194. doi: 10.1126/science.163.3872.1193. [DOI] [PubMed] [Google Scholar]
  3. Connolly J. H., Allen I. V., Hurwitz L. J., Millar J. H. Measles-virus antibody and antigen in subacute sclerosing panencephalitis. Lancet. 1967 Mar 11;1(7489):542–544. doi: 10.1016/s0140-6736(67)92117-4. [DOI] [PubMed] [Google Scholar]
  4. Dawson J. R. Cellular Inclusions in Cerebral Lesions of Lethargic Encephalitis. Am J Pathol. 1933 Jan;9(1):7–16.3. [PMC free article] [PubMed] [Google Scholar]
  5. Dayan A. D., Gostling J. V., Greaves J. L., Stevens D. W., Woodhouse M. A. Evidence of a pseudomyxovirus in the brain in subacute sclerosing leucoencephalitis. Lancet. 1967 May 6;1(7497):980–981. doi: 10.1016/s0140-6736(67)92360-4. [DOI] [PubMed] [Google Scholar]
  6. ENDERS J. F., KATZ S. L., MILOVANOVIC M. V., HOLLOWAY A. Studies on an attenuated measles-virus vaccine. I. Development and preparations of the vaccine: technics for assay of effects of vaccination. N Engl J Med. 1960 Jul 28;263:153–159. doi: 10.1056/NEJM196007282630401. [DOI] [PubMed] [Google Scholar]
  7. Freeman J. M. The clinical spectrum and early diagnosis of Dawson's encephalitis, with preliminary notes on treatment. J Pediatr. 1969 Oct;75(4):590–603. doi: 10.1016/s0022-3476(69)80454-3. [DOI] [PubMed] [Google Scholar]
  8. Herndon R. M., Rubinstein L. J. Light and electron microscopy observations on the development of viral particles in the inclusions of Dawson's encephalitis (subacute sclerosing panencephalitis). Neurology. 1968 Jan;18(1 Pt 2):8–20. doi: 10.1212/wnl.18.1_part_2.008. [DOI] [PubMed] [Google Scholar]
  9. Horta-Barbosa L., Fuccillo D. A., Sever J. L., Zeman W. Subacute sclerosing panencephalitis: isolation of measles virus from a brain biopsy. Nature. 1969 Mar 8;221(5184):974–974. doi: 10.1038/221974a0. [DOI] [PubMed] [Google Scholar]
  10. Katz M., Oyanagi S., Koprowski H. Subacute sclerosing panencephalitis: structures resembling myxovirus nucleocapsids in cells cultured from brain. Nature. 1969 May 31;222(5196):888–890. doi: 10.1038/222888a0. [DOI] [PubMed] [Google Scholar]
  11. LANDAU W. M., LUSE S. A. Relapsing inclusion encephalitis (Dawson type) of eight years' duration. Neurology. 1958 Sep;8(9):669–676. doi: 10.1212/wnl.8.9.669. [DOI] [PubMed] [Google Scholar]
  12. Legg N. J. Virus antibodies in subacute sclerosing panencephalitis: a study of 22 patients. Br Med J. 1967 Aug 5;3(5561):350–352. doi: 10.1136/bmj.3.5561.350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lennette E. H., Magoffin R. L., Freeman J. M. Immunologic evidence of measles virus as an etiologic agent in subacute sclerosing panencephalitis. Neurology. 1968 Jan;18(1 Pt 2):21–29. doi: 10.1212/wnl.18.1_part_2.021. [DOI] [PubMed] [Google Scholar]
  14. MALAMUD N., HAYMAKER W., PINKERTON H. Inclusion encephalitis; with a clinicopathologic report of three cases. Am J Pathol. 1950 Jan;26(1):133-53, incl 5 pl. [PMC free article] [PubMed] [Google Scholar]
  15. Nakai T., Shand F. L., Howatson A. F. Development of measles virus in vitro. Virology. 1969 May;38(1):50–67. doi: 10.1016/0042-6822(69)90127-5. [DOI] [PubMed] [Google Scholar]
  16. Payne F. E., Baublis J. V., Itabashi H. H. Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis. N Engl J Med. 1969 Sep 11;281(11):585–589. doi: 10.1056/NEJM196909112811103. [DOI] [PubMed] [Google Scholar]
  17. Périer O., Vanderhaeghen J. J. Indications étiologiques apportées par la microscopie électronique dans certaines encéphalites humaines. Rev Neurol (Paris) 1966 Aug;115(2):250–254. [PubMed] [Google Scholar]
  18. Périer O., Vanderhaeghen J. J., Pelc S. Subacute sclerosing leuco-encephalitis. Electron microscopic finding in two cases with inclusion bodies. Acta Neuropathol. 1967 Jul 5;8(4):362–380. doi: 10.1007/BF00696673. [DOI] [PubMed] [Google Scholar]
  19. REYNOLDS E. S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963 Apr;17:208–212. doi: 10.1083/jcb.17.1.208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Resnick J. S., Engel W. K., Sever J. L. Subacute sclerosing panencephalitis. Spontaneous improvement in a patient with elevated measles antibody in blood and spinal fluid. N Engl J Med. 1968 Jul 18;279(3):126–129. doi: 10.1056/NEJM196807182790303. [DOI] [PubMed] [Google Scholar]
  21. Robb R. M., Watters G. V. Ophthalmic manifestations of subacute sclerosing panencephalitis. Arch Ophthalmol. 1970 Apr;83(4):426–435. doi: 10.1001/archopht.1970.00990030426007. [DOI] [PubMed] [Google Scholar]
  22. Schubert P. Atypischer Fall einer subakuten sklerosierenden Leukoencephalitis (van Bogaert) Acta Neuropathol. 1966 Jan 14;6(1):93–97. doi: 10.1007/BF00691086. [DOI] [PubMed] [Google Scholar]
  23. Shaw C. M., Buchan G. C., Carlson C. B. Myxovirus as a possible etiologic agent in subacute inclusion body-encephalitis. N Engl J Med. 1967 Sep 7;277(10):511–515. doi: 10.1056/NEJM196709072771004. [DOI] [PubMed] [Google Scholar]
  24. Shaw C. M. Electron microscopic observations in subacute sclerosing panencephalitis. A supplementary report. Neurology. 1968 Jan;18(1 Pt 2):144–145. doi: 10.1212/wnl.18.1_part_2.144. [DOI] [PubMed] [Google Scholar]
  25. TZITSIKAS H., RDZOK E. J., VATTER A. E. Staining procedures for ultrathin sections of tissues embedded in polyester resin. Stain Technol. 1961 Nov;36:355–359. doi: 10.3109/10520296109113310. [DOI] [PubMed] [Google Scholar]
  26. Tellez-Negal I., Harter D. H. Subacute sclerosing leukoencephalitis: ultrastructure of intranuclear and intracytoplasmic inclusions. Science. 1966 Nov 18;154(3751):899–901. doi: 10.1126/science.154.3751.899. [DOI] [PubMed] [Google Scholar]
  27. Thiry L., Dachy A., Lowenthal A. Measles antibodies in patients with various types of measles infection. Arch Gesamte Virusforsch. 1969;28(3):278–284. doi: 10.1007/BF01240943. [DOI] [PubMed] [Google Scholar]
  28. Ulrich J., Kidd M. Subacute inclusion body encephalitis. A histological and electron microscopical study. Acta Neuropathol. 1966 Jul 7;6(4):359–370. doi: 10.1007/BF00688164. [DOI] [PubMed] [Google Scholar]
  29. VAN BUREN J. M. A case of subacute inclusion encephalitis studied by the metallic methods. J Neuropathol Exp Neurol. 1954 Jan;13(1):230–247. doi: 10.1097/00005072-195401000-00019. [DOI] [PubMed] [Google Scholar]
  30. Zeman W., Kolar O. Reflections on the etiology and pathogenesis of subacute sclerosing panencephalitis. Neurology. 1968 Jan;18(1 Pt 2):1–7. doi: 10.1212/wnl.18.1_part_2.1. [DOI] [PubMed] [Google Scholar]
  31. Zu Rhein G. M., Chou S. M. Subacute sclerosing panencephalitis. Ultrastructural study of a brain biopsy. Neurology. 1968 Jan;18(1 Pt 2):146–160. doi: 10.1212/wnl.18.1_part_2.146. [DOI] [PubMed] [Google Scholar]

Articles from The American Journal of Pathology are provided here courtesy of American Society for Investigative Pathology

RESOURCES