(A) Effect of CGP64222 on HIV-1LAV replication in human lymphocytes. Supernant RT activity was determined on days 3, 6, 10, 13, and 17. Each data point represents the mean of 6 replicates (variation <10%). •, Untreated cells; ○, 3 μM CGP64222; ▵, 10 μM CGP64222; ▴, 30 μM CGP64222. (B) Effect of CGP64222 and the Arg5 peptide on HIV-1LAV replication in human lymphocytes. Cumulative supernatant RT activity from days 3, 6, 10, 13, and 17 is shown. Data represent the mean values of 6 replicates (variation <10%). •, Untreated cells; ○, 30 μM Arg5 peptide; ▵, 30 μM CGP64222.