Effect of MDMA on social play behaviour in peri-adolescent male wild-type rats. Thirty minutes before the 15-min test, the animals were treated with 0, 0.5, 2 or 5 mg/kg MDMA (s.c.). The data represent mean ± SEM of the number of pins, pounces and boxing/wresting episodes (a) and mean ± SEM of the duration of social exploration, following/chasing and social grooming (b). Asterisk, p < 0.05 vs saline; double cross, p < 0.05 vs 0.5 mg/kg MDMA