Table 1.
a.Summary of geometric means (CV%) of pharmacokinetic parameters on day 1 after a single dose of 40 mg atomoxetine and on day 10 after multiple doses of 80 mg qd atomoxetine
| Arithmetic mean (SD) | Geometric mean (CV%) | |||
|---|---|---|---|---|
| Parameters | (N = 16)Single dose (40 mg) | (N = 16)Multiple dose (80 mg) | Single dose(40 mg) | Multipledose (80 mg) |
| Cmax or Cmax,ss (ng ml−1) | 449 (144) | 1020 (334) | 427 (34.0) | 965 (36.2) |
| Cav,ss (ng ml−1) | – | 297 (143) | – | 260 (60.5) |
| tmax* or tmax,ss* (h) | 1.25 (0.50–4.00) | 1.50 (0.50–4.00) | – | – |
| AUC0–∞ or AUCt,ss (h ng−1 ml−1) | 3630 (1730) | 7120 (3430) | 3170 (62.4) | 6240 (60.5) |
| CL/F or CLss/F (l h−1 kg−1) | 0.241 (0.151) | 0.242 (0.142) | 0.204 (62.7) | 0.208 (61.4) |
| t1/2† (h) | 4.15 (2.44–5.94) | 4.31 (2.22–6.39) | – | – |
| LI | – | 0.993 (0.158) | – | 0.982 (15.3) |
| RA | – | 1.02 (0.159) | – | 1.01 (14.9) |