Table 2.

Mean (SD) values for maximum plasma concentration (C_max), time to maximum plasma concentration (t_max) and area under the curve (AUC(0,5 h)) for fluticasone and budesonide when inhaled with and without prior methacholine-induced bronchoconstriction

	Without bronchoconstriction	With bronchoconstriction	Difference (95% CI)	P value
Fluticasone
Cmax (ng ml−1)	0.12 (0.07)	0.06 (0.04)	0.06 (0.03, 0.08)	<0.001
tmax (h)	1.21 (0.91)	0.78 (0.62)	0.43 (−0.01, 0.87)	0.05
AUC(0,5 h) (ng ml−1 h)	0.40 (0.23)	0.16 (0.10)	0.23 (0.14, 0.33)	<0.001
Budesonide
Cmax (ng ml−1)	1.67 (0.82)	1.16 (0.48)	0.51 (0.16, 0.85)	0.007
tmax (h)	0.21 (0.24)	0.23 (0.24)	−0.02 (−0.15, 0.12)
AUC(0,5 h) (ng ml−1 h)	2.87 (1.19)	2.28 (0.90)	0.6 (0.02, 1.17)	0.04