Table 1.
Examples of known and no known drug–drug interactions
| Drug–Drug | Event | Mechanism of interaction |
|---|---|---|
| Known interaction | ||
| Methotrexate-diclofenac | Bone marrow depression | Inhibition of renal elimination of methotrexate |
| Simvastatin-ciclosporin | Myopathy | CYP450 inhibition |
| Ketoconazole-terfenadine | Torsade de pointes | CYP450 inhibition |
| Cisapride-erythromycin | Torsade de pointes | CYP450 inhibition |
| No known interaction | ||
| Fexofenadine-ketoconazole | Torsade de pointes | – |
| Methotrexate-rofecoxib | Bone marrow depression | – |
| Fluvastatin-ciclosporin | Myopathy | – |
| Cisapride-azithromycin | Torsade de pointes | – |